Dr Charles Haworth, MD FRCP

Dr Charles HaworthConsultant in Respiratory Medicine
Director, Cambridge Centre for Lung Infection


Contact details
Switchboard 01480 830541     Fax 01480 364330

Lynn Manfroi
Tel 01480 364122     Email lynn.manfroi@papworth.nhs.uk

• Respiratory Medicine (adults)

Specialist Clinical Interests
• Cystic Fibrosis
• Bronchiectasis
• Asthma / COPD with infection
• Complex lung infection (including Pseudomonas aeruginosa, Non Tuberculous Mycobacteria and Aspergillus)
• Primary Ciliary Dyskinesia
• Immunodeficiency

Research Interests
• Epidemiology and treatment of lung infection in patients with CF and non-CF bronchiectasis.
• Bone pathophysiology and treatment in patients with chronic lung disease.

Professional Profile
Charles Haworth is Director of the Cambridge Centre for Lung Infection (incorporating The Adult Cystic Fibrosis Centre, The Lung Defence Clinic and The Immunology Clinic) at Papworth Hospital. He is also an Honorary Consultant at Addenbrooke’s Hospital in Cambridge. He trained at the Manchester Adult Cystic Fibrosis Centre, The Royal Brompton Hospital and The Hammersmith Hospital in London, before moving to Cambridge in 2003. He is a co-author of the North American CF Foundation, the UK CF Trust and European CF Society Bone Health Guidelines and has performed a number of external peer review visits of adult Cystic Fibrosis Centres on behalf of the UK CF Trust / British thoracic Society. He is currently co-chairing the European Cystic Fibrosis Society working group on Non Tuberculous Mycobacterial infection. He collaborates with several research groups at the University of Cambridge and is the chief investigator of multicentre novel therapy clinical trials in CF and non-CF bronchiectasis. He is a member of the North American CF Foundation Data and Safety Monitoring Board.

Education and Training
• 1993 M.B.Ch.B. Manchester University
• 1996 M.R.C.P. London
• 2003 M.D. Manchester University
• 2003 CCST in Respiratory Medicine
• 2003 Respiratory Medicine Specialist Register
• 2007 F.R.C.P. London

Current membership(s) of professional, national and regional bodies and university posts
• British Thoracic Society
• American Thoracic Society
• Fellow, Royal College of Physicians of London

Recent and Important Publications
Peer reviewed publications:

Haworth CS, Selby PL, Webb AK, Mawer EB, Adams JE, Freemont AJ. Severe bone pain after intravenous pamidronate in adult patients with cystic fibrosis. Lancet 1998;352:1753-1754

Haworth CS, Niven R, Moorcroft AJ, Phillips A, Dodd ME, Webb AK. Acute anaphylaxis following midline catheterisiation in a patient with cystic fibrosis. Thorax 1999;54:747.

Haworth CS, Freemont AJ, Webb AK, Dodd ME, Selby PL, Mawer EB, Adams JE. Hip fracture and bone histomorphometry in a young adult with cystic fibrosis. Eur Resp J 1999;14:478-479

Haworth CS, Selby PL, Webb AK, Dodd ME, Musson H, Niven R M, Economou G, Horrocks AW, Freemont AJ, Mawer EB, Adams JE. Low bone mineral density in cystic fibrosis adults. Thorax 1999;54:961-967 Editorial: Conway SP. Bone mineral density in adults with cystic fibrosis. Thorax 1999;54:957

Haworth CS, Dodd ME, Atkins M, Woodcock AA, Webb AK. Pneumothorax in cystic fibrosis adults dependent on nasal intermittent positive pressure ventilation (NIPPV): a management dilemma. Thorax 2000;55:620-623.

Haworth CS, Webb AK, Egan JJ, Selby PL, Hasleton PS, Bishop PW, Freemont AJ. Bone histomorphometry in adult patients with cystic fibrosis. Chest 2000;118:434-439

Dodd ME, Kellet F, Davis A, Simpson JCG, Webb AK, Haworth CS, Niven RML. An audit of oxygen prescribing by doctors: a specific oxygen prescription chart improves clinical practice. BMJ 2000;321:864-865

Haworth CS, Selby PL, Adams JE, Mawer EB, Horrocks AW, Webb AK. The effect of intravenous pamidronate in adults with cystic fibrosis. Thorax 2001;56:314-316

Haworth CS, Selby PL, Horrocks AW, Mawer EB, Adams JE, Webb AK. A prospective study of change in bone mineral density over one year in 114 adults with cystic fibrosis. Thorax 2002;57:719-723

Haworth CS, Selby PL, Webb AK, Martin L, Elborn S, Sharples L, Adams JE. Inflammatory related changes in bone mineral content in adults with cystic fibrosis. Thorax 2004;59:613-617

Haworth CS, Jones AM, Selby PL, Webb AK, Adams JE. Randomised double blind placebo controlled trial investigating the effect of calcium and vitamin D supplementation on bone mineral density and bone metabolism in adult patients with cystic fibrosis. J Cyst Fibros 2004;3:233-236

Chapman E, Landy A, Lyon A, Haworth CS, Bilton D. End of life care for adult cystic fibrosis patients: Facilitating a good enough death. J Cyst Fibros 2005;4(4):249-257

Aris RM on behalf of the Cystic Fibrosis Foundation Consensus Bone Health Group. Guide to bone health and disease in cystic fibrosis. J Clin Endocrinol Metab 2005;90:1888-1896

Shead EL, Haworth CS, Gunn E, Bilton D, Scott MA, Compston JE. Osteoclastogenesis during infective exacerbations in patients with cystic fibrosis. Am J Resp Crit Care Med 2006;174(3):306-311

Fowler SJ, French J, Screaton NJ, Foweraker J, Condliffe A, Haworth CS, Exley AR, Bilton D. Non-tuberculous mycobacteria in bronchiectasis: prevalence and patient characteristics. Eur Resp J 2006;28(6):1204-1210

Shead EF, Haworth CS, Condliffe AM, McKeon DJ, Scott MA, Compston JE. Cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in human bone. Thorax. 2007;62(7):650-651

Adler AI, Gunn E, Haworth CS, Bilton D. Characteristics of adults with and without cystic fibrosis related diabetes. Diabetic Medicine 2007;24:1143-1148

Nash KL, Allison ME, McKeon D, Lomas DA, Haworth CS, Bilton D, Alexander GJ. A single centre experience of liver disease in adults with cystic fibrosis 1995-2005. J Cyst Fibros 2008;7(3):252-257

Adler AI, Shine BS, Chamnan P, Haworth CS, Bilton D. Genetic determinants and epidemiology of cystic fibrosis-related diabetes: results from a British cohort of children and adults. Diabetes Care 2008;31(9):1789-1794.

Barker HC, Haworth CS, Williams D, Roberts P, Bilton D. Clostridium difficile pancolitis in adults with cystic fibrosis. J Cyst Fibros. 2008;7(5):444-447

Gilham MI, Sundaram S, Laughton CR, Haworth CS, Bilton D, Foweraker JE. Variable antibiotic susceptibility in populations of Pseudomonas aeruginosa infecting patients with bronchiectasis. J Antimicrob Chemother 2009;63:728-732

McKeon DJ, Cadwalladwe KA, Idreis S, Cowburn AS, Pasteur MC, Barker HC, Haworth CS, Bilton D, Chilvers ER, Condliffe AM. Cystic fibrosis neutrophils have normal intrinsic reactive oxygen species generation. Eur Respir J 2010;35:1264-1272

Chamnan P, Shine BS, Haworth CS, Bilton D, Adler AI. Diabetes as determinants of mortality in cystic fibrosis. Diabetes care 2010;33:311-316

Shead EF, Haworth CS, Barker HC, Bilton D, Compston JE. Osteoclast function, bone turnover and inflammatory cytokines during infective exacerbations of cystic fibrosis. J Cyst Fibros 2010;9:93-98

Sermet-Gaudelus I, Bianchi ML, Garabedian M, Aris R, Morton A, Hardin D, Elkin SL, Compston JE, Conway P, Castanet M, Wolfe S, Haworth CS. European cystic fibrosis bone mineralisation guidelines. J Cyst Fibros 2011;Suppl 2:S16-23

Adler AI, Shine B, Haworth CS, Leelarathna L, Bilton D. Hyperglycaemia and death in cystic fibrosis related diabetes. Diabetes Care 2011;34:1577-1588

Renna M, Schaffner C, Brown K, Shang S, Henao Tamayo M, Hegyi K, Grimsey NJ, Cusens D, Coulter S, Cooper J, Bowden AR, Newton S, Kampmann B, Helm J, Jones A, Haworth CS, Basaraba RJ, DeGroote MA, Ordway DJ, Rubinsztein DC, Floto RA. Azithromycin blocks autophagy and may predispose to mycobacterial infection. J Clin Invest. 2011 Sep 1;121(9):3554-3563

Haworth CS, Sharples L, Hughes V, Elkin SL, Hodson ME, Conway SP, Etherington C, Elborn JS, Rendall J, Wheaton E, Kadri E, Elliott J, Barker HC, Bearcroft PWP, Hlaing T, Compston JE. Multicentre trial of weekly risedronate on bone density in adults with cystic fibrosis. J Cyst Fibros. 2011;10:470-476

Book chapters:
Haworth CS, Webb AK. Cystic Fibrosis. In: Grassi C, ed. Pulmonary Diseases. London: McGraw-Hill, 1999:115-125

Haworth CS, Elkin SL. Bone Mineralisation in Cystic Fibrosis. In: Webb AK and Ratjen F, Eds. Cystic Fibrosis. Eur Resp J Monograph April 2006

Elkin SL, Haworth CS. Cystic Fibrosis Related Low Bone Mineral Density. In: Hodson, Geddes & Bush A, Eds. Cystic Fibrosis, Third Edition, 2007.

Haworth CS. Metabolic and musculoskeletal effects of cystic fibrosis. In: Innes A, Cunningham S, Horsley A, Eds. Cystic Fibrosis, Oxford Respiratory Medicine, 2010.

Haworth CS. Antibiotic treatment strategies in adults with bronchiectasis. In Floto RA and Haworth CS. Eds. Bronchiectasis. Eur Resp J Monograph, Number 52, June 2011